USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: P31323 USC-OGP 2-DE database:  P31323 P31323 General information about the entry View entry in simple text format Entry name KAP3_HUMAN Primary accession number P31323 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=cAMP-dependent protein kinase type II-beta regulatory subunit;. Gene name Name=PRKAR2B Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0062: pI=4.69; Mw=52782 SPOT OGP-0063: pI=4.66; Mw=52549 SPOT OGP-0121: pI=4.91; Mw=36422 Cross-references UniProtKB/Swiss-Prot P31323; KAP3_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name KAP3_HUMAN Primary accession number P31323 Secondary accession number(s) A4D0R9 Sequence was last modified on  September 23, 2008 (version 3) Annotations were last modified on  March 15, 2017 (version 166) Name and origin of the protein Description RecName: Full=cAMP-dependent protein kinase type II-beta regulatory subunit; Gene name Name=PRKAR2B Encoded on Name=PRKAR2B Keywords cAMP; cAMP-binding; Cell membrane; Complete proteome; Cytoplasm; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M31158; AAA60099.1; -; mRNA EMBL AK291441; BAF84130.1; -; mRNA EMBL CH236947; EAL24395.1; -; Genomic_DNA EMBL CH471070; EAW83390.1; -; Genomic_DNA CCDS CCDS5740.1; -; . PIR A40915; OKHUR2; . RefSeq NP_002727.2; NM_002736.2; . UniGene Hs.433068; -; . ProteinModelPortal P31323; -; . SMR P31323; -; . BioGrid 111563; 61; . DIP DIP-554N; -; . IntAct P31323; 32; . MINT MINT-2782562; -; . STRING 9606.ENSP00000265717; -; . BindingDB P31323; -; . DrugBank DB02527; Cyclic Adenosine Monophosphate; . GuidetoPHARMACOLOGY 1475; -; . iPTMnet P31323; -; . PhosphoSitePlus P31323; -; . BioMuta PRKAR2B; -; . DMDM 206729918; -; . OGP P31323; -; . EPD P31323; -; . MaxQB P31323; -; . PaxDb P31323; -; . PeptideAtlas P31323; -; . PRIDE P31323; -; . DNASU 5577; -; . Ensembl ENST00000265717; ENSP00000265717; ENSG00000005249; . GeneID 5577; -; . KEGG hsa:5577; -; . UCSC uc003vdx.4; human; . CTD 5577; -; . DisGeNET 5577; -; . GeneCards PRKAR2B; -; . H-InvDB HIX0025309; -; . HGNC HGNC:9392; PRKAR2B; . HPA HPA008421; -; . MIM 176912; gene; . neXtProt NX_P31323; -; . OpenTargets ENSG00000005249; -; . PharmGKB PA33758; -; . eggNOG KOG1113; Eukaryota; . eggNOG COG0664; LUCA; . GeneTree ENSGT00530000062947; -; . HOGENOM HOG000196668; -; . HOVERGEN HBG002025; -; . InParanoid P31323; -; . KO K04739; -; . OMA QENERGT; -; . OrthoDB EOG091G0F1K; -; . PhylomeDB P31323; -; . TreeFam TF314920; -; . Reactome R-HSA-163615; PKA activation; . Reactome R-HSA-164378; PKA activation in glucagon signalling; . Reactome R-HSA-180024; DARPP-32 events; . Reactome R-HSA-2565942; Regulation of PLK1 Activity at G2/M Transition; . Reactome R-HSA-380259; Loss of Nlp from mitotic centrosomes; . Reactome R-HSA-380270; Recruitment of mitotic centrosome proteins and complexes; . Reactome R-HSA-380284; Loss of proteins required for interphase microtubule organization from the centrosome; . Reactome R-HSA-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; . Reactome R-HSA-432040; Vasopressin regulates renal water homeostasis via Aquaporins; . Reactome R-HSA-5610787; Hedgehog 'off' state; . Reactome R-HSA-5620912; Anchoring of the basal body to the plasma membrane; . Reactome R-HSA-8854518; AURKA Activation by TPX2; . Reactome R-HSA-983231; Factors involved in megakaryocyte development and platelet production; . SIGNOR P31323; -; . ChiTaRS PRKAR2B; human; . GeneWiki PRKAR2B; -; . GenomeRNAi 5577; -; . PRO PR:P31323; -; . Proteomes UP000005640; Chromosome 7; . Bgee ENSG00000005249; -; . CleanEx HS_PRKAR2B; -; . ExpressionAtlas P31323; baseline and differential; . Genevisible P31323; HS; . GO GO:0005952; C:cAMP-dependent protein kinase complex; IEA:Ensembl; . GO GO:0005813; C:centrosome; IDA:UniProtKB; . GO GO:0097546; C:ciliary base; TAS:Reactome; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0043198; C:dendritic shaft; ISS:ParkinsonsUK-UCL; . GO GO:0043197; C:dendritic spine; ISS:ParkinsonsUK-UCL; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0045121; C:membrane raft; IEA:Ensembl; . GO GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl; . GO GO:0043025; C:neuronal cell body; IEA:Ensembl; . GO GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl; . GO GO:0005886; C:plasma membrane; IDA:UniProtKB; . GO GO:0030552; F:cAMP binding; IEA:UniProtKB-KW; . GO GO:0004862; F:cAMP-dependent protein kinase inhibitor activity; IDA:BHF-UCL; . GO GO:0008603; F:cAMP-dependent protein kinase regulator activity; IDA:BHF-UCL; . GO GO:0034236; F:protein kinase A catalytic subunit binding; IPI:BHF-UCL; . GO GO:0031625; F:ubiquitin protein ligase binding; IDA:UniProtKB; . GO GO:0034199; P:activation of protein kinase A activity; TAS:Reactome; . GO GO:0007596; P:blood coagulation; TAS:Reactome; . GO GO:0071377; P:cellular response to glucagon stimulus; TAS:Reactome; . GO GO:0097711; P:ciliary basal body docking; TAS:Reactome; . GO GO:0006631; P:fatty acid metabolic process; IEA:Ensembl; . GO GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0035556; P:intracellular signal transduction; TAS:ProtInc; . GO GO:0007612; P:learning; IEA:Ensembl; . GO GO:2000480; P:negative regulation of cAMP-dependent protein kinase activity; IDA:BHF-UCL; . GO GO:0003091; P:renal water homeostasis; TAS:Reactome; . GO GO:0097332; P:response to antipsychotic drug; IEA:Ensembl; . GO GO:0097338; P:response to clozapine; IEA:Ensembl; . Gene3D 1.20.890.10; -; 1; . Gene3D 2.60.120.10; -; 2; . InterPro IPR012198; cAMP_dep_PK_reg_su; . InterPro IPR003117; cAMP_dep_PK_reg_su_I/II_a/b; . InterPro IPR018490; cNMP-bd-like; . InterPro IPR018488; cNMP-bd_CS; . InterPro IPR000595; cNMP-bd_dom; . InterPro IPR014710; RmlC-like_jellyroll; . Pfam PF00027; cNMP_binding; 2; . Pfam PF02197; RIIa; 1; . PIRSF PIRSF000548; PK_regulatory; 1; . SMART SM00100; cNMP; 2; . SMART SM00394; RIIa; 1; . SUPFAM SSF47391; SSF47391; 1; . SUPFAM SSF51206; SSF51206; 2; . PROSITE PS00888; CNMP_BINDING_1; 2; . PROSITE PS00889; CNMP_BINDING_2; 2; . PROSITE PS50042; CNMP_BINDING_3; 2; .

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